Journal article

Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis

Stuart K Roberts, Simone Strasser, Amanda J Nicoll, William Kemp, Ammar Majeed, Joanne Mitchell, Katherine Stuart, Paul Gow, Siddharth Sood, Gerry MacQuillan, Jacob George, Jonathan Mitchell, Geoffrey W McCaughan

Scandinavian Journal of Gastroenterology | TAYLOR & FRANCIS LTD | Published : 2020

Abstract

BACKGROUND: As data is limited on the outcomes of calcineurin inhibitors (CNI) in autoimmune hepatitis (AIH), we evaluated the efficacy and safety of CNI in AIH patients who failed prior treatment(s). METHODS: A retrospective study was performed of AIH patients who received cyclosporine A (CsA) and/or tacrolimus (TAC) after prior treatment(s) failure. Records were reviewed for baseline demographic and clinical characteristics, and treatment outcomes. The primary outcome was biochemical remission. Results: Thirty-three AIH patients received CNI across seven liver centers:17 received CsA, 21 TAC and 5 TAC after CsA failure/intolerance. 82% received CNI for an insufficient response to treatment..

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