Orexin-1 receptor signaling within the lateral hypothalamus, but not bed nucleus of the stria terminalis, mediates context-induced relapse to alcohol seeking
Erin J Campbell, Mitchell KR Hill, Xavier J Maddern, Shubo Jin, Terence Y Pang, Andrew J Lawrence
Journal of Psychopharmacology | SAGE PUBLICATIONS LTD | Published : 2020
BACKGROUND: The lateral hypothalamic orexin (hypocretin) system has a well-established role in the motivation for reward. This has particular relevance to substance use disorders since orexin-1 receptors play a critical role in alcohol-seeking behavior, acting at multiple nodes in relapse-associated networks. AIMS: This study aimed to further our understanding of the role of orexin-1 receptor signaling within the lateral hypothalamus and bed nucleus of the stria terminalis, specifically in context-induced relapse to alcohol-seeking following punishment-imposed abstinence. METHODS: We trained inbred male alcohol-preferring rats to self-administer alcohol in one environment or context (Context..View full abstract
Awarded by National Health and Medical Research Council
Awarded by Jack Brockhoff Early Career Researcher Grant
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by National Health and Medical Research Council Project Grants (1105741, 1159032), and a Jack Brockhoff Early Career Researcher Grant (4496-2018). AJL is a NHMRC Principal Fellow (1116930). The authors acknowledge the Victorian State Government Operational Infrastructure Scheme.