Journal article

Automated radiosynthesis of [Ga-68]Ga-PSMA-11 and [Lu-177]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications

Christian W Wichmann, Uwe Ackermann, Stan Poniger, Kenneth Young, Benjamin Nguyen, Gordon Chan, John Sachinidis, Andrew M Scott

Journal of labelled compounds & radiopharmaceuticals | WILEY | Published : 2020

Abstract

Prostate-specific membrane antigen (PSMA)-targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly changing clinical practice. To facilitate clinical trials, fully automated procedures for the radiosyntheses of [68 Ga]Ga-PSMA-11 and [177 Lu]Lu-PSMA-617 were developed from commercially available precursors using the cassette based iPHASE MultiSyn module. Formulated and sterile radiopharmaceuticals were obtained in 76 ± 3% (n = 20) and 91 ± 4% (n = 15) radiochemical yields after 17 and 20 min, respectively. Radiochemical purity was always >95% and molar activities exceeded 792 ± 100 and 88 ± 6 GBq/μmol, respectively. Quality control showed conformity with all relevant..

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Grants

Awarded by Victorian Cancer Agency


Awarded by National Health and Medical Research Council


Funding Acknowledgements

Victorian Cancer Agency, Grant/Award Number: 1063413; Operational Infrastructure Support from Victorian Government; National Health and Medical Research Council, Grant/Award Numbers: 1092788, 1143710