Journal article
In vivo hippocampal subfield volumes in bipolar disorder—A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group
UK Haukvik, TP Gurholt, S Nerland, T Elvsåshagen, TN Akudjedu, M Alda, D Alnæs, S Alonso-Lana, J Bauer, BT Baune, F Benedetti, M Berk, F Bettella, E Bøen, CM Bonnín, P Brambilla, EJ Canales-Rodríguez, DM Cannon, X Caseras, O Dandash Show all
Human Brain Mapping | WILEY | Published : 2022
DOI: 10.1002/hbm.25249
Abstract
The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly sma..
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Awarded by William K. Warren Foundation
Funding Acknowledgements
Instituto de Salud Carlos III, FEDER Funds/European Regional Development Fund, Grant/Award Numbers: PI19/00394, CPII19/00009; Departament de Salut de la Generalitat de Catalunya, Grant/Award Number: SLT002/16/00331; FAPESP; Singapore Bioimaging Consortium, Grant/Award Number: RP C-009/2006; NWO/ZonMW VENI-Grant, Grant/Award Number: 016.126.059; Netherlands Organization for Health Research and Development (ZonMw), Program Mental Health, Education of Investigators in Mental Health, Grant/Award Number: 100-002-034; NIGMS, Grant/Award Number: P20GM121312; NIMH, Grant/Award Number: R21MH113871; William K Warren Foundation; National Research Foundation, South Africa and University Research Committee, University of Cape Town; Wellcome Trust Strategic Award, Grant/Award Number: 104036/Z/14/Z; European Community's Seventh Framework Program, Grant/Award Number: FP7/2007-2013; Lansdowne Foundation; Australian National Medical and Health Research Council, Grant/Award Numbers: 1063960, 1066177, 1037196; Ebbe Froland Foundation; Oslo University Hospital-Rikshospitalet; PRISMA UT-Colciencias and Convocatoria Programatica Ciencias de la Salud 2014-2015 by CODI-Universidad de Antioquia U de A; Interdisciplinary Center for Clinical Research (IZKF) of the Medical Faculty of Munster, Grant/Award Numbers: SEED11/18, Dan3/012/17; German Research Foundation, Grant/Award Numbers: KO 4291/3-1, NE 2254/1-2, KR 3822/7-2, KR 3822/5-1, KI 588/14-2, KI 588/14-1, DA 1151/5-2, DA 1151/5-1, FOR2107, SFB-TRR58; Bipolar Disorder Research Network (BDRN), Grant/Award Number: 17319; Italian Ministry of Health, Grant/Award Numbers: RF-2011-02350980, RF-2016-02364582; European Regional Development Fund/European Social Fund, Grant/Award Numbers: PI18/00877, PI18/00810, CD18/00029, CD16/00264, MSII16/00018; Instituto de Salud Carlos III; Generalitat de Catalunya, Grant/Award Number: 2017SGR1271; National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship, Grant/Award Numbers: APP1156072, 1059660; AstraZeneca; Brain & Behavior Research Foundation; Dalhousie Clinical Research Scholarship; Nova Scotia Health Research Foundation; Canadian Institutes of Health Research, Grant/Award Numbers: 142255, 106469, 103703; Health Research Board, Grant/Award Number: HRA-POR-324; South-Eastern Norway Regional Health Authority, Grant/Award Numbers: 2014097, 2017112, 2017097; KG Jebsen Stiftelsen; The Research Council of Norway, Grant/Award Numbers: 288083, 250358, 213700, 223273; National Institutes of Health (NIH), Grant/Award Numbers: R01MH116147, U54EB020403, 5T32MH073526, T32AG058507, R01AG059874, R01MH117601, U54 EB020403