Journal article

Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk

Howard HF Tang, Anna Lang, Shu Mei Teo, Louise M Judd, Ronald Gangnon, Michael D Evans, Kristine E Lee, Rose Vrtis, Patrick G Holt, Robert F Lemanske, Daniel J Jackson, Kathryn E Holt, Michael Inouye, James E Gern

Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2021

Abstract

BACKGROUND: Studies indicate that the nasal microbiome may correlate strongly with the presence or future risk of childhood asthma. OBJECTIVES: In this study, we tested whether developmental trajectories of the nasopharyngeal microbiome in early life and the composition of the microbiome during illnesses were related to risk of childhood asthma. METHODS: Children participating in the Childhood Origins of Asthma study (N = 285) provided nasopharyngeal mucus samples in the first 2 years of life, during routine healthy study visits (at 2, 4, 6, 9, 12, 18, and 24 months of age), and during episodes of respiratory illnesses, all of which were analyzed for respiratory viruses and bacteria. We iden..

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Grants

Awarded by National Institutes of Health, National Heart, Lung, and Blood Institute


Awarded by National Center for Advancing Translational Sciences


Awarded by Office of the National Institutes of Health Director


Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

Supported by National Institutes of Health, National Heart, Lung, and Blood Institute (grant PO1 HL70381) , the National Center for Advancing Translational Sciences (grant UL1TR000427) , and the Office of the National Institutes of Health Director (grant no. UG3/UH3 OD023282) . M.I. was supported by the Australian National Health and Medical Research Council (grant 1049539) . H.H.F.T. was supported by an Australian National Health and Medical Research Council PhD scholarship.