Journal article

Transmission of Oscillatory Volumes into the Preterm Lung during Noninvasive High-Frequency Ventilation

Vincent D Gaertner, Andreas D Waldmann, Peter G Davis, Dirk Bassler, Laila Springer, Jessica Thomson, David G Tingay, Christoph M Ruegger

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AMER THORACIC SOC | Published : 2021

Abstract

Rationale: There is increasing evidence for a clinical benefit of noninvasive high-frequency oscillatory ventilation (nHFOV) in preterm infants. However, it is still unknown whether the generated oscillations are effectively transmitted to the alveoli.Objectives: To assess magnitude and regional distribution of oscillatory volumes (VOsc) at the lung level.Methods: In 30 prone preterm infants enrolled in a randomized crossover trial comparing nHFOV with nasal continuous positive airway pressure, electrical impedance tomography recordings were performed. During nHFOV, the smallest amplitude to achieve visible chest wall vibration was used, and the frequency was set at 8 hertz.Measurements and ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by German Research Society (DFG-grant)


Awarded by TUFF Habilitation Program


Awarded by Career Development Fellowships GNT


Awarded by Swiss National Science Foundation (Early Postdoctoral Mobility fellowship)


Awarded by Endeavour Research Fellowship (Australia)


Funding Acknowledgements

Supported by the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia); the National Health and Medical Research Council (Practitioner Fellowship GNT 1059111 [P.G.D.]); the German Research Society (DFG-grant Nr. LO 2162/1-1 [L.S.]); the TUFF Habilitation Program (TUFF 2459-0-0 [L.S.]); Career Development Fellowships GNT 11123859 and 1057514 [D.G.T.]); the Swiss National Science Foundation (Early Postdoctoral Mobility fellowship P2ZHP3_161749 [C.M.R.]); and the Swiss Society of Neonatology (Milupa Fellowship Award [C.M.R.]). V.D.G. received an Endeavour Research Fellowship (Australia, ERF_RDDH_5276_2016). SenTec AG had no involvement in study design, implementation, analysis, interpretation, and reporting.