Journal article

Gestational Vitamin D and Offspring Bone Measures: Is the Association Independent of Maternal Bone Quality?

Natalie K Hyde, Sharon L Brennan-Olsen, John D Wark, Sarah M Hosking, Julie A Pasco



Previously we have reported an association between maternal vitamin D and offspring bone as measured by dual-energy X-ray absorptiometry. It is plausible that shared genetics might confound associations between maternal vitamin D in pregnancy and offspring bone measures. We aimed to determine whether such associations are independent of maternal bone quality. Data for this analysis were derived from 168 mother-child pairs who returned at the 11-year follow-up of the vitamin D in pregnancy study. Gestational 25-hydroxyvitamin D [25(OH)D] was assessed by radioimmunoassay in early pregnancy at recruitment (before 16 weeks gestation) and later in pregnancy (28-32 weeks gestation). Bone quality w..

View full abstract


Awarded by NHMRC

Funding Acknowledgements

We would like to thank participants of the Vitamin D in Pregnancy study for their continued involvement. Our appreciation is also extended to study staff and former investigators, particularly Ruth Morley, Kathy Bennett, and Amelia Betson, for their roles in the collecting clinical data. The initial phases of this study were funded by a project grant from the National Health and Medical Research Council (NHMRC) Australia, and the follow-up was supported by a grant from the Bupa Health Foundation. NKH and SMH are supported by Dean's Research Postdoctoral Fellowships (Deakin University). SLB-O is supported by an NHMRC Career Development Fellowship (1107510).