Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments
Gerwyn Morris, Basant K Puri, Lisa Olive, Andre Carvalho, Michael Berk, Ken Walder, Lise Tuset Gustad, Michael Maes
BMC Medicine | BMC | Published : 2020
BACKGROUND: Potential routes whereby systemic inflammation, oxidative stress and mitochondrial dysfunction may drive the development of endothelial dysfunction and atherosclerosis, even in an environment of low cholesterol, are examined. MAIN TEXT: Key molecular players involved in the regulation of endothelial cell function are described, including PECAM-1, VE-cadherin, VEGFRs, SFK, Rho GEF TRIO, RAC-1, ITAM, SHP-2, MAPK/ERK, STAT-3, NF-κB, PI3K/AKT, eNOS, nitric oxide, miRNAs, KLF-4 and KLF-2. The key roles of platelet activation, xanthene oxidase and myeloperoxidase in the genesis of endothelial cell dysfunction and activation are detailed. The following roles of circulating reactive oxyg..View full abstract
Awarded by NHMRC
MB is supported by a NHMRC Senior Principal Research Fellowship (1059660 and 1156072); LO is supported by an NHMRC Early Career Fellowship (APP1158487).