Journal article

Efficacy and Harms of Pharmacological Interventions for Anxiety after Traumatic Brain Injury: Systematic Review

Amelia J Hicks, Fiona J Clay, Malcolm Hopwood, Amelia C James, Luke A Perry, Mahesh Jayaram, Rachel Batty, Jennie L Ponsford

Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2020

Abstract

After a traumatic brain injury (TBI), many persons experience significant and debilitating problems with anxiety. The aim of this systematic review was to critically evaluate the evidence regarding efficacy of pharmacological interventions for anxiety after TBI. We reviewed studies published in English before July 2020 and included original research on pharmacological interventions for anxiety after TBI in adults ≥16 years of age. MEDLINE, PubMed, CINAHL, EMBASE, PsycINFO, and CENTRAL databases were searched, with additional searching of key journals, clinical trials registries, and international drug regulators. The primary outcomes of interest were reduction in symptoms of anxiety and occu..

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Grants

Awarded by Transport Accident Commission (TAC) through the Institute for Safety, Compensation and Recovery Research (ISCRR)


Funding Acknowledgements

The project was funded by the Transport Accident Commission (TAC) through the Institute for Safety, Compensation and Recovery Research (ISCRR; Grant Number 2010-2015 [#141]). The funder was not involved in any other aspect of the project. This includes study design, data collection, analysis and interpretation of data, writing of the report, or decision to submit the article for publication.