Journal article

Genetic and environmental causes of variation in epigenetic aging across the lifespan

Shuai Li, Tuong L Nguyen, Ee Ming Wong, Pierre-Antoine Dugue, Gillian S Dite, Nicola J Armstrong, Jeffrey M Craig, Karen A Mather, Perminder S Sachdev, Richard Saffery, Joohon Sung, Qihua Tan, Anbupalam Thalamuthu, Roger L Milne, Graham G Giles, Melissa C Southey, John L Hopper

CLINICAL EPIGENETICS | BMC | Published : 2020

Abstract

BACKGROUND: DNA methylation-based biological age (DNAm age) is an important biomarker for adult health. Studies in specific age ranges have found widely varying results about its genetic and environmental causes of variation. However, these studies are not able to provide a comprehensive view of the causes of variation over the lifespan. RESULTS: In order to investigate the genetic and environmental causes of DNAm age variation across the lifespan, we pooled genome-wide DNA methylation data for 4217 people aged 0-92 years from 1871 families. DNAm age was calculated using the Horvath epigenetic clock. We estimated familial correlations in DNAm age for monozygotic (MZ) twin, dizygotic (DZ) twi..

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Grants

Awarded by Victorian Cancer Agency


Awarded by Cancer Council Victoria


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Cure Cancer Australia


Awarded by NHMRC


Awarded by Centre of Research Excellence Grant from the NHMRC


Awarded by National Breast Cancer Foundation


Awarded by Australian Research Council (ARC) Strategic Award Grant of the Ageing Well, Ageing Productively Program


Awarded by Centre for Research Excellence Grant from the NHMRC


Funding Acknowledgements

This work was supported by grants from the Victorian Cancer Agency (Grant No. ECRF19020), Cancer Council Victoria (Grant No. 180626), and National Health and Medical Research Council (NHMRC, Grant No. 057873). SL is a Victorian Cancer Agency Early Career Research Fellow (ECRF19020). SL and TLN were supported by the Cancer Council Victoria Postdoctoral Research Fellowship and the Picchi Award from the Victorian Comprehensive Cancer Centre. TLN was supported by the Cure Cancer Australia (APP1159399). MCS is a NHMRC Senior Research Fellow (APP1155163). JLH is a NHMRC Senior Principal Research Fellow. The PETS was supported by grants from the NHMRC (Grant No. 1146333 to JC). The AMDTSS was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (Grant No. 1079102) from the NHMRC. The AMDTSS was supported by NHMRC (Grant Nos. 1050561 and 1079102), Cancer Australia and National Breast Cancer Foundation (Grant No. 509307). The OATS was funded by a NHMRC and Australian Research Council (ARC) Strategic Award Grant of the Ageing Well, Ageing Productively Program (Grant No. 401162) and NHMRC Project Grants (Grant Nos. 1045325 and 1085606). The OATS was facilitated through Twins Research Australia, a national resource in part supported by a Centre for Research Excellence Grant (Grant No. 1079102) from the NHMRC. The MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further augmented by NHMRC grants numbers 209057 and 396414 and by infrastructure provided by the Cancer Council Victoria. Additional support was received from NHMRC Project Grant Nos. 1011618, 1026892, 1027505, 1050198, and 1043616. The MCCS research was in part supported by a Program Grant from the NHMRC (Grant No. 1074383) and an award from Victorian Breast Cancer Research Consortium (PI MCS).