Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes

WS Beattie; M Lalu; M Bocock; S Feng; DN Wijeysundera; P Nagele; LA Fleisher; A Kurz; B Biccard; K Leslie; S Howell; G Landoni; H Grocott; A Lamy; T Richards; P Myles; TJ Gan; P Peyton; D Sessler; M Tramèr; A Cyna; GS De Oliveira; C Wu; M Jensen; H Kehlet; M Botti; O Boney; G Haller; M Grocott; T Cook; M Neuman; D Story; R Gruen; S Bampoe; L Evered; D Scott; B Silbert; D van Dijk; C Kalkman; M Chan; R Eckenhoff; L Rasmussen; L Eriksson; RJ Bartlett; R McMonnies; J Gerstl; M Jay; D Kishlyansky; M Machina; M Bobcock; R Pearse; M Mythen; J Canet; A Moller; T Gin; M Schultz; P Pelosi; M Gabreu; E Futier; B Creagh-Brown; T Abbott; A Klein; T Corcoran; DJ Cooper; S Dieleman; E Diouf; D McIlroy; R Bellomo; A Shaw; J Prowle; K Karkouti; J Billings; D Mazer; M Jayarajah; M Murphy; J Bartoszko; R Sneyd; S Morris; R George; R Moonesinghe; M Shulman; M Lane-Fall; U Nilsson; N Stevenson; J Cooper; W van Klei; L Cabrini; T Miller; N Pace; S Jackson; D Buggy; T Short; B Riedel; V Gottumukkala; B Alkhaffaf; M Johnson

Journal article

Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes

WS Beattie, M Lalu, M Bocock, S Feng, DN Wijeysundera, P Nagele, LA Fleisher, A Kurz, B Biccard, K Leslie, S Howell, G Landoni, H Grocott, A Lamy, T Richards, P Myles, TJ Gan, P Peyton, D Sessler, M Tramèr Show all

British Journal of Anaesthesia | ELSEVIER SCI LTD | Published : 2021

DOI: 10.1016/j.bja.2020.09.023

Abstract

Background: Adverse cardiovascular events are a leading cause of perioperative morbidity and mortality. The definitions of perioperative cardiovascular adverse events are heterogeneous. As part of the international Standardized Endpoints in Perioperative Medicine initiative, this study aimed to find consensus amongst clinical trialists on a set of standardised and valid cardiovascular outcomes for use in future perioperative clinical trials. Methods: We identified currently used perioperative cardiovascular outcomes by a systematic review of the anaesthesia and perioperative medicine literature (PubMed/Ovid, Embase, and Cochrane Library). We performed a three-stage Delphi consensus-gaining p..

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