Conservative or liberal oxygen therapy in adults after cardiac arrest An individual-level patient data meta-analysis of randomised controlled trials
Paul J Young, Michael Bailey, Rinaldo Bellomo, Stephen Bernard, Janet Bray, Pekka Jakkula, Markku Kuisma, Diane Mackle, Daniel Martin, Jerry P Nolan, Rakshit Panwar, Matti Reinikainen, Markus B Skrifvars, Matt Thomas
RESUSCITATION | ELSEVIER IRELAND LTD | Published : 2020
AIM: The effect of conservative versus liberal oxygen therapy on mortality rates in post cardiac arrest patients is uncertain. METHODS: We undertook an individual patient data meta-analysis of patients randomised in clinical trials to conservative or liberal oxygen therapy after a cardiac arrest. The primary end point was mortality at last follow-up. RESULTS: Individual level patient data were obtained from seven randomised clinical trials with a total of 429 trial participants included. Four trials enrolled patients in the pre-hospital period. Of these, two provided protocol-directed oxygen therapy for 60 min, one provided it until the patient was handed over to the emergency department sta..View full abstract
This research was conducted during the tenure of a Health Research Council of New Zealand Clinical Practitioner Fellowship held by Paul Young. Janet Bray is funded by a Heart Foundation of Australia Fellowship.