Sub-Inhibitory Clindamycin and Azithromycin reduce S. aureus Exoprotein Induced Toxicity, Inflammation, Barrier Disruption and Invasion
Hua Hu, Mahnaz Ramezanpour, Andrew J Hayes, Sha Liu, Alkis J Psaltis, Peter-John Wormald, Sarah Vreugde
Journal of Clinical Medicine | MDPI | Published : 2019
BACKGROUND: Chronic rhinosinusitis (CRS) is defined as a chronic inflammation of the nose and paranasal sinus mucosa associated with relapsing infections-particularly with S. aureus. Long-term treatments with protein synthesis inhibitor antibiotics have been proposed to reduce inflammation in the context chronic severe inflammatory airway pathologies, including CRS. This study assessed the effect of subinhibitory clindamycin and azithromycin on S. aureus exoprotein induced inflammation, toxicity and invasiveness. METHODS: S. aureus ATCC51650 and two clinical isolates grown in planktonic and biofilm form were treated with subinhibitory clindamycin and azithromycin. Exoproteins were collected ..View full abstract
This work is supported by grants from The Hospital Research Foundation and The Garnett Passe and Rodney Williams Memorial Foundation to P.-J.W. and S.V.