Journal article

Cellular and Molecular Mechanisms of CD8( ) T Cell Differentiation, Dysfunction and Exhaustion

Daniel J Verdon, Matthias Mulazzani, Misty R Jenkins

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2020

Abstract

T cells follow a triphasic distinct pathway of activation, proliferation and differentiation before becoming functionally and phenotypically "exhausted" in settings of chronic infection, autoimmunity and in cancer. Exhausted T cells progressively lose canonical effector functions, exhibit altered transcriptional networks and epigenetic signatures and gain constitutive expression of a broad coinhibitory receptor suite. This review outlines recent advances in our understanding of exhausted T cell biology and examines cellular and molecular mechanisms by which a state of dysfunction or exhaustion is established, and mechanisms by which exhausted T cells may still contribute to pathogen or tumou..

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