Survival, Dependency, and Health-Related Quality of Life in Patients With Ruptured Intracranial Aneurysm: 10-Year Follow-up of the United Kingdom Cohort of the International Subarachnoid Aneurysm Trial
Xinyang Hua, Alastair Gray, Jane Wolstenholme, Philip Clarke, Andrew J Molyneux, Richard SC Kerr, Alison Clarke, Mary Sneade, Oliver Rivero-Arias
NEUROSURGERY | OXFORD UNIV PRESS INC | Published : 2021
BACKGROUND: Previous analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on clinical outcomes after treatment of a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling. OBJECTIVE: To evaluate the long-term quality-adjusted life years (QALYs) gained of endovascular coiling compare to neurosurgical clipping in the UK cohort of ISAT. METHODS: Between September 12, 1994 and May 1, 2002, patients with ruptured intracranial aneurysms who were assumed treatment equipoise were randomly allocated to either neurosurgical clipping or endovascular coiling. We followed-up 1644 patients in 22 UK neurosurgical centers for a minimum of 1..View full abstract
Awarded by Medical Research Council
The ISAT was funded by a Medical Research Council grant (number G0700479, ended in June 2013; previous grant number G9401611, which ended in June 2007). The research was supported by the National Institute for Health Research Oxford Biomedical Research Centre.