Cochlear microphonic latency predicts outer hair cell function in animal models and clinical populations
Christofer Bester, Stefan Weder, Aaron Collins, Adrian Dragovic, Kate Brody, Amy Hampson, Stephen O'Leary
Hearing Research | ELSEVIER | Published : 2020
As recently reported, electrocochleography recorded in cochlear implant recipients showed reduced amplitude and shorter latency in patients with more severe high-frequency hearing loss compared with those with some residual hearing. As the response is generated primarily by receptor currents in outer hair cells, these variations in amplitude and latency may indicate outer hair cell function after cochlear implantation. We propose that an absence of latency shift when the cochlear microphonic is measured on two adjacent electrodes indicates an absence or dysfunction of outer hair cells between these electrodes. We test this preclinically in noise deafened guinea pigs (2 h of a 124 dB HL, 16-2..View full abstract
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Awarded by National Health and Medical Research Council (Australia)
The authors would like to thank the engineers from Cochlear Ltd for assistance in developing software, the audiologists and staff at the Royal Victorian Eye and Ear Hospital Cochlear Implant Clinic for their support during the project, the surgeons and surgical registrars of the Clinic. Stephen O'Leary was funded by the National Health and Medical Research Council (Australia), GNT0628679 and GNT1078673.