Journal article

The pontine Kolliker-Fuse nucleus gates facial, hypoglossal, and vagal upper airway related motor activity

M Dutschmann, TG Bautista, P Trevizan-Bau, RR Dhingra, W Furuya

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | ELSEVIER | Published : 2021

Abstract

The pontine Kölliker-Fuse nucleus (KFn) is a core nucleus of respiratory network that mediates the inspiratory-expiratory phase transition and gates eupneic motor discharges in the vagal and hypoglossal nerves. In the present study, we investigated whether the same KFn circuit may also gate motor activities that control the resistance of the nasal airway, which is of particular importance in rodents. To do so, we simultaneously recorded phrenic, facial, vagal and hypoglossal cranial nerve activity in an in situ perfused brainstem preparation before and after bilateral injection of the GABA-receptor agonist isoguvacine (50-70 nl, 10 mM) into the KFn (n = 11). Our results show that bilateral i..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Awarded by Melbourne Research Scholarship (University of Melbourne)


Funding Acknowledgements

This work was supported by research grants from the National Health and Medical Research Council of Australia (APP1165529); and Australian Research Council (Discovery project DP170104861); PT-B is funded by Melbourne Research Scholarship (University of Melbourne; 181858).