Journal article

Simultaneous BOLD-fMRI and constant infusion FDG-PET data of the resting human brain

Sharna D Jamadar, Phillip GD Ward, Thomas G Close, Alex Fornito, Malin Premaratne, Kieran O'Brien, Daniel Stab, Zhaolin Chen, N Jon Shah, Gary F Egan

Scientific Data | NATURE RESEARCH | Published : 2020

Abstract

Simultaneous [18 F]-fluorodeoxyglucose positron emission tomography and functional magnetic resonance imaging (FDG-PET/fMRI) provides the capability to image two sources of energetic dynamics in the brain - cerebral glucose uptake and the cerebrovascular haemodynamic response. Resting-state fMRI connectivity has been enormously useful for characterising interactions between distributed brain regions in humans. Metabolic connectivity has recently emerged as a complementary measure to investigate brain network dynamics. Functional PET (fPET) is a new approach for measuring FDG uptake with high temporal resolution and has recently shown promise for assessing the dynamics of neural metabolism. S..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Australian Research Council (ARC)


Awarded by ARC Centre of Excellence for Integrative Brain Function


Awarded by ARC Discovery Early Career Researcher Award


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was supported by an Australian Research Council (ARC) Linkage Project (LP170100494) that includes financial support from Siemens Healthineers. SDJ, PGDW & GFE are supported by the ARC Centre of Excellence for Integrative Brain Function (CE140100007). SDJ is supported by an ARC Discovery Early Career Researcher Award (DE150100406) and National Health and Medical Research Council Fellowship (APP1174164). The authors acknowledge Alexandra Carey & Richard McIntyre from Monash Biomedical Imaging for assistance with data collection and assistance with BIDS preparation. We also acknowledge Disha Sasan, Winnie Orchard and Irene Graafsma for their assistance in acquiring data.