Journal article

Descending Modulation of Laryngeal Vagal Sensory Processing in the Brainstem Orchestrated by the Submedius Thalamic Nucleus

Stuart B Mazzone, Tara G Bautista, Anthony JM Verberne, Matthew W Trewella, Michael J Farrell, Alice E McGovern

The Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2020

Abstract

The nodose and jugular vagal ganglia supply sensory innervation to the airways and lungs. Jugular vagal airway sensory neurons wire into a brainstem circuit with ascending projections into the submedius thalamic nucleus (SubM) and ventrolateral orbital cortex (VLO), regions known to regulate the endogenous analgesia system. Here we investigate whether the SubM-VLO circuit exerts descending regulation over airway vagal reflexes in male and female rats using a range of neuroanatomical tracing, reflex physiology, and chemogenetic techniques. Anterograde and retrograde neuroanatomical tracing confirmed the connectivity of the SubM and VLO. Laryngeal stimulation in anesthetized rats reduced respi..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia Fellowship


Awarded by NHMRC


Funding Acknowledgements

A.E.M. is currently funded by National Health and Medical Research Council (NHMRC) of Australia Fellowship APP1121376. This research was supported by NHMRC Grant 1078943 to S.B.M. The authors declare no competing financial interests.