Journal article
Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report
SG Williams, HX Aw Yeang, C Mitchell, F Caramia, DJ Byrne, SB Fox, S Haupt, RB Schittenhelm, PJ Neeson, Y Haupt, SP Keam
BMC Urology | BMC | Published : 2020
Abstract
Background: Understanding the drivers of recurrence in aggressive prostate cancer requires detailed molecular and genomic understanding in order to aid therapeutic interventions.We provide here a case report of histological, transcriptional, proteomic, immunological, and genomic features in a longitudinal study of multiple biopsies from diagnosis, through treatment, and subsequent recurrence. Case presentation: Here we present a case study of a male in 70 s with high-grade clinically-localised acinar adenocarcinoma treated with definitive hormone therapy and radiotherapy. The patient progressed rapidly with rising PSA and succumbed without metastasis 52 months after diagnosis.We identified t..
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Funding Acknowledgements
Tissue collection was partially funded by a Prostate Cancer Foundation USA (Creativity award) and a Victorian Cancer Agency award to S.G.W. Subsequent molecular analyses were supported by the PeterMac Foundation and an NHMRC Program Grant. Salary support was provided to S.P.K by a Cancer Council Victoria Grant-In-Aid. Core facilities were also supported by the Australian Cancer Research Foundation (ACRF).