Journal article

Structural Neuroplastic Responses Preserve Functional Connectivity and Neurobehavioural Outcomes in Children Born Without Corpus Callosum

Vanessa Siffredi, Maria G Preti, Valeria Kebets, Silvia Obertino, Richard J Leventer, Alissandra McIlroy, Amanda G Wood, Vicki Anderson, Megan M Spencer-Smith, Dimitri Van de Ville



The corpus callosum is the largest white matter pathway in the brain connecting the two hemispheres. In the context of developmental absence (agenesis) of the corpus callosum (AgCC), a proposed candidate for neuroplastic response is strengthening of intrahemispheric pathways. To test this hypothesis, we assessed structural and functional connectivity in a uniquely large cohort of children with AgCC (n = 20) compared with typically developing controls (TDC, n = 29), and then examined associations with neurobehavioral outcomes using a multivariate data-driven approach (partial least squares correlation, PLSC). For structural connectivity, children with AgCC showed a significant increase in int..

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Awarded by European Research Council Consolidator Fellowship

Funding Acknowledgements

The Boninchi Foundation from the University of Geneva; the Victorian Government's Operational Infrastructure Support Program; and the Murdoch Children's Research Institute. European Research Council Consolidator Fellowship (682734 to A.W.). A Melbourne Children's Clinician Scientist Fellowship (to R.L.). The Australian National Health andMedical Research Council Senior Practitioner Fellowship (to V.A.); The CIBM Center for Biomedical Imaging (to M. G. P.).