Journal article

Structural Neuroplastic Responses Preserve Functional Connectivity and Neurobehavioural Outcomes in Children Born Without Corpus Callosum

Vanessa Siffredi, Maria G Preti, Valeria Kebets, Silvia Obertino, Richard J Leventer, Alissandra McIlroy, Amanda G Wood, Vicki Anderson, Megan M Spencer-Smith, Dimitri Van de Ville

CEREBRAL CORTEX | OXFORD UNIV PRESS INC | Published : 2021

Abstract

The corpus callosum is the largest white matter pathway in the brain connecting the two hemispheres. In the context of developmental absence (agenesis) of the corpus callosum (AgCC), a proposed candidate for neuroplastic response is strengthening of intrahemispheric pathways. To test this hypothesis, we assessed structural and functional connectivity in a uniquely large cohort of children with AgCC (n = 20) compared with typically developing controls (TDC, n = 29), and then examined associations with neurobehavioral outcomes using a multivariate data-driven approach (partial least squares correlation, PLSC). For structural connectivity, children with AgCC showed a significant increase in int..

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Grants

Awarded by European Research Council Consolidator Fellowship


Funding Acknowledgements

The Boninchi Foundation from the University of Geneva; the Victorian Government's Operational Infrastructure Support Program; and the Murdoch Children's Research Institute. European Research Council Consolidator Fellowship (682734 to A.W.). A Melbourne Children's Clinician Scientist Fellowship (to R.L.). The Australian National Health andMedical Research Council Senior Practitioner Fellowship (to V.A.); The CIBM Center for Biomedical Imaging (to M. G. P.).