Journal article
Structural Neuroplastic Responses Preserve Functional Connectivity and Neurobehavioural Outcomes in Children Born without Corpus Callosum
V Siffredi, MG Preti, V Kebets, S Obertino, RJ Leventer, A Mcilroy, AG Wood, V Anderson, MM Spencer-Smith, D Van De Ville
Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2021
Abstract
The corpus callosum is the largest white matter pathway in the brain connecting the two hemispheres. In the context of developmental absence (agenesis) of the corpus callosum (AgCC), a proposed candidate for neuroplastic response is strengthening of intrahemispheric pathways. To test this hypothesis, we assessed structural and functional connectivity in a uniquely large cohort of children with AgCC (n = 20) compared with typically developing controls (TDC, n = 29), and then examined associations with neurobehavioral outcomes using a multivariate data-driven approach (partial least squares correlation, PLSC). For structural connectivity, children with AgCC showed a significant increase in int..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
The Boninchi Foundation from the University of Geneva; the Victorian Government's Operational Infrastructure Support Program; and the Murdoch Children's Research Institute. European Research Council Consolidator Fellowship (682734 to A.W.). A Melbourne Children's Clinician Scientist Fellowship (to R.L.). The Australian National Health andMedical Research Council Senior Practitioner Fellowship (to V.A.); The CIBM Center for Biomedical Imaging (to M. G. P.).