Journal article

Serum leukotriene B4 and hydroxyeicosatetraenoic acid in the prediction of pre-eclampsia

Leilani L Santos, Dagmar Wertaschnigg, Daniel L Rolnik, Fabricio Da Silva Costa, Argyro Syngelaki, Evdokia Dimitriadis, Kypros H Nicolaides

PLACENTA | W B SAUNDERS CO LTD | Published : 2021

Abstract

INTRODUCTION: Pre-eclampsia (PE) affects 2-8% of pregnancies worldwide. Despite identification of numerous possible biomarkers, accurate prediction and early diagnosis of PE remain challenging. We examined the potential of leukotriene B4 (LTB4) and 15-hydroxyeicosatetraenoic acid (15(S)-HETE) as biomarkers of PE by comparing serum levels at three gestational age (GA) groups between normotensive pregnancies and asymptomatic women who subsequently developed preterm or term-PE. METHODS: This is a case-control study drawn from a prospective study of adverse pregnancy outcomes with serum samples collected at 19-24 weeks (n = 48), 30-34 weeks (n = 101) and 35-37 weeks (n = 54) GA. LTB4 and 15(S)-H..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Paracelsus Medical University Salzburg, Austria (PMU Research Fund - PMU FFF)


Funding Acknowledgements

ED was supported by a senior research fellowship from the National Health and Medical Research Council of Australia (grant numbers 1117033 and 1098332). DW was supported by a grant from the Paracelsus Medical University Salzburg, Austria (PMU Research Fund - PMU FFF Number: L-18/02/006-WET) and by Drs Haackert Foundation, Germany.