The control of Nedd4 family interacting protein 1 (Ndfip1) expression and its binding partners

Abstract

The Nedd4 family interacting protein 1 (Ndfip1) is a neuroprotective protein, highly up-regulated in the neuron following brain injury. Many fundamental questions regarding the functions and regulations of Ndfip1 remained unsolved. Therefore, this study aimed to investigate Ndfip1 from three different aspects: 1) novel drugs or compounds which up-regulate the Ndfip1 levels, 2) novel binding partners of Ndfip1 and 3) specific functions and downstream processes of following the interaction between Ndfip1 and PTEN. A high-throughput screening method was developed in this study in order to search the novel drugs or compounds which up-regulate Ndfip1..