A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.
Guoliang Zhang, Nicole A deWeerd, Sebastian A Stifter, Lei Liu, Boping Zhou, Wenfei Wang, Yiping Zhou, Binwu Ying, Xuejiao Hu, Antony Y Matthews, Magda Ellis, James A Triccas, Paul J Hertzog, Warwick J Britton, Xinchun Chen, Carl G Feng
Nature Communications | Published : 2018
Type I interferons (IFN), best known for their anti-viral functions, have been shown to impair host resistance to intracellular bacteria in mice. However, the precise role of type I IFN signaling in bacterial infection in humans is unclear. Here, we show that genetic variation in the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and an increased risk of viral hepatitis in Chinese populations. Receptor mutagenesis and cell signaling studies establish that the IFNAR1 mutation corresponding to a proline deletion in the hinge region of the membrane-proximal domain of IFNAR1 decreases the binding affinity of IFNAR1 to IFN-β, impeding type I IFN signaling. Our findi..View full abstract