Journal article

MicroRNA as Type I Interferon-Regulated Transcripts and Modulators of the Innate Immune Response.

Samuel C Forster, Michelle D Tate, Paul J Hertzog

Frontiers in Immunology | Published : 2015


Type I interferons (IFNs) are an important family of cytokines that regulate innate and adaptive immune responses to pathogens, in cancer and inflammatory diseases. While the regulation and role of protein-coding genes involved in these responses are well characterized, the role of non-coding microRNAs in the IFN responses is less developed. We review the emerging picture of microRNA regulation of the IFN response at the transcriptional and post-transcriptional level. This response forms an important regulatory loop; several microRNAs target transcripts encoding components at many steps of the type I IFN response, both production and action, at the receptor, signaling, transcription factor, ..

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University of Melbourne Researchers