Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon.
Belinda J Thomas, Rebecca A Porritt, Paul J Hertzog, Philip G Bardin, Michelle D Tate
Scientific Reports | Published : 2014
Glucocorticosteroids (GCS) are used on a daily basis to reduce airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). This treatment is usually escalated during acute disease exacerbations, events often associated with virus infections. We examined the impact of GCS on anti-viral defences and virus replication and assessed supplementary interferon (IFN) treatment. Here, we report that treatment of primary human airway cells in vitro with GCS prior to rhinovirus (RV) or influenza A virus (IAV) infection significantly reduces the expression of innate anti-viral genes and increases viral replication. Mice given intranasal treatment with GCS prior to IAV infection develo..View full abstract