Toll-like receptor signalling and the clinical benefits that lie within.
B Verstak, P Hertzog, A Mansell
Inflamm Res | Published : 2007
TLRs are of crucial importance to the innate immune system by recognising molecules that are broadly shared by pathogens but distinguishable from host molecules. The innate immune system works to defend the body from microbial infection by initiating inflammation, the extreme form of which is sepsis. The discovery that endogenous ligands, as well as microbial components, are recognised by TLRs, raise the possibility of these receptors and their associated adapter molecules, as potential targets for the development of agonists and antagonists for the treatment of various pathological diseases, and their manipulation as potential adjuvants in vaccine development. By elucidating the mechanisms ..View full abstract