Testing broad-spectrum and isoform-preferring HCN channel blockers for anticonvulsant properties in mice
Qays Kharouf, Paulo Pinares-Garcia, M Novella Romanelli, Christopher A Reid
Epilepsy Research | ELSEVIER | Published : 2020
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and consequently as targets for anticonvulsant drugs. Consistent with this, broad-spectrum block of HCN-mediated current (Ih) reduces seizure susceptibility in a variety of epilepsy models. However, HCN channel isoforms have distinct biophysical characteristics and anatomical expression suggesting that they may play different roles in setting neuronal excitability. Here we confirm that the broad-spectrum blocker ivabradine is effective at reducing seizure susceptibility in the s.c.PTZ seizure assay and extend this, showing efficacy of this drug in a thermogenic assay that m..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
This work was supported by National Health and Medical Research Council (NHMRC) Program Grant  to CAR, and NHMRC Project Grant  to CAR.