Journal article

Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis

Myrte Strik, Declan T Chard, Iris Dekker, Kim A Meijer, Anand JC Eijlers, Matteo Pardini, Bernard MJ Uitdehaag, Scott C Kolbe, Jeroen JG Geurts, Menno M Schoonheim

MULTIPLE SCLEROSIS JOURNAL | SAGE PUBLICATIONS LTD | Published : 2020

Abstract

BACKGROUND: Network abnormalities could help explain physical disability in multiple sclerosis (MS), which remains poorly understood. OBJECTIVE: This study investigates functional network efficiency changes in the sensorimotor system. METHODS: We included 222 MS patients, divided into low disability (LD, Expanded Disability Status Scale (EDSS) ⩽3.5, n = 185) and high disability (HD, EDSS ⩾6, n = 37), and 82 healthy controls (HC). Functional connectivity was assessed between 23 sensorimotor regions. Measures of efficiency were computed and compared between groups using general linear models corrected for age and sex. Binary logistic regression models related disability status to local functio..

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Grants

Awarded by Dutch MS Research Foundation


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the Dutch MS Research Foundation (grant numbers 08-650, 13-820, 14-358e) and Melbourne University (Melbourne Research Scholarship).