Thesis / Dissertation

Protease-activated receptor-2 in bone morphogenesis and pathology: Is par2 essential in osteoblastic bone homeostasis?

Mohammad Reza Sanaei, Eleanor J Mackie (ed.)

Published : 2017

Abstract

Protease activated receptor-2 (PAR2) is a member of the small family of protease-activated G protein-coupled receptors. PAR2 is widely expressed in most tissues including bone and has been shown to regulate cell proliferation and survival, cytokine production and release as well as nociception. Recent unpublished data suggest that PAR2 plays a role in bone homeostasis by regulating the osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs). Due to the potential impact of such regulation on age-related bone loss and osteoporosis, the current study undertook to investigate the hypothesis that PAR2 activation regulates the determination of mesenchymal cell fate such that ost..

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