Immunoglobulin allotypes, antibody-dependent neutrophil phagocytosis: impact on HIV and influenza

Abstract

Antibodies (Abs) are highly functional immune proteins. Abs can deactivate pathogens through neutralization and mediating various Fc receptor (FcR) functions. Two common FcR-mediated functions are Ab-dependent cellular cytotoxicity (ADCC) and Ab-dependent (cellular) phagocytosis (ADCP or ADP). These functions are triggered by binding of the Fc region of Abs to FcRs on innate immune cell surface. Studies including analyses of the moderately protective human phase III RV144 HIV vaccine trial suggest that antibodies with the ability to mediate FcR functions may be important in HIV protection and control. IgG, the most abundant Ab isotype, has different subclasses including IgG1, IgG2, IgG3, and..