Thesis / Dissertation

Characterization of specific inhibitors of Porphyromonas gingivalis gingipains based on their cognate propeptides

Abu Sayeed Mohammad Mahmud, Christine Seers (ed.)

Published : 2019


Porphyromonas gingivalis is a pathogenic bacterium that has a significant role in the progression of chronic periodontal disease. The cell-surface proteases RgpA, RgpB and Kgp collectively known as the gingipains, are major virulence factors of P. gingivalis. Furthermore, P. gingivalis is unable to metabolize sugars for energy production and relies on the gingipains to degrade host proteins to produce small peptides which it uses for nutrition. Thus, strategies that inhibit gingipain function may be of use in reducing the incidence and severity of periodontitis. The Arg-gingipains, RgpA and RgpB and Lys-gingipain Kgp are secreted from P. gingivalis as inactive prodomain-bearing precursors. T..

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University of Melbourne Researchers