Thesis / Dissertation

Radiolabelled peptides and amino acids for PET imaging of cancer

Ashleigh Lilian Farnsworth, Craig Hutton (ed.)

Published : 2019

Abstract

Cell surface receptors, which are overexpressed in cancerous tumours, are feasible molecular targets for tumour imaging. The transmembrane G-protein coupled receptor CXCR4 is overexpressed in tumours and has a crucial role in organ-specific metastasis of tumour cells. Cyclic pentapeptides such as FC131 and analogues have been developed to bind with high affinity and specificity to CXCR4. Unfortunately, when FC131 is radiolabelled and evaluated as a PET imaging agent, it demonstrates high retention in the liver due to its lipophilic character. Sulfonation of aromatic groups, such as the phenolic group in tyrosine, results in a significant reduction of a peptide’s lipophilic character. Evaluat..

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University of Melbourne Researchers