Thesis / Dissertation

Response of subchondral bone and articular cartilage to joint surface incongruity: an equine osteochondral defect model

Megan Elizabeth Thomas, Robert Whitton (ed.)

Published : 2019

Abstract

Many diseases and injuries of synovial joints result in a focal loss of articular surface congruity. These conditions are known to lead to degenerative changes within the affected joint and subsequent osteoarthritis (OA). Incongruity due to loss of articular cartilage is also a feature of OA itself. However there is little work specifically investigating how the tissues of a synovial joint respond to loss of congruity. The aim of this study was to observe how articular cartilage and subchondral bone (SCB) respond to a focal loss of surface congruity using an equine model. It was hypothesised that the degree of remodelling and bone volume of SCB is dependent on local loading of the overlying ..

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