Thesis / Dissertation

Early intervention models of diabetes care to address adverse glycaemia in hospital

Mervyn Kyi, Spiros Fourlanos (ed.)

Published : 2019

Abstract

Diabetes affects one quarter of individuals in hospital and contributes to worse clinical and economic outcomes. Acute hyperglycaemia causes immune dysfunction, proinflammatory and prothrombotic changes, and endothelial dysfunction, leading to increased risk of hospital-acquired infections, and cardiovascular and renal complications. Acute hypoglycaemia also causes proinflammatory and prothrombotic changes, endothelial dysfunction, and neuroglycopaenia-related complications. ‘Adverse glycaemia’ describes both extremes of hypoglycaemia and hyperglycaemia (defined as glucose 15 mmol/L), that are associated with adverse pathophysiology and adverse outcomes in hospital. Adverse glycaemia remains..

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