Thesis / Dissertation

The regulation of skin-homing receptors and its implications on T helper cells following localized Herpes Simplex Virus infection

Shinta Trilaksmi Dewi, Andrew Brooks (ed.)

Published : 2019

Abstract

Effective cellular immunity relies not only on the appropriate differentiation of antigen-specific T cells directed toward particular pathogens but also on the targeted migration of these cells to the sites of infection. E-selectin ligand (ESL) is a homing receptor widely recognized for its role in supporting the migration of leukocytes to the skin particularly during non-specific inflammation. However, the role of ESL in the migration of CD4+ T cells to the skin during viral infection and its regulation of expression on these cells are less understood. This thesis aimed to explore these aspects by utilizing an in vivo mouse model of localized skin infection with herpes simplex virus-1 (HSV..

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