Thesis / Dissertation

Optimising the functional maturity of kidney organoids for screening nephrotoxic Drugs

Ying-Chen Soo, Melissa Little (ed.)

Published : 2019

Abstract

Kidneys are uniquely vulnerable to drug toxicity due to their role in filtering substances from the blood. Filtration and urine production takes places in specialised tubules called nephrons, which are divided into segments with functionally distinct cell types that express transporters and receptors for transporting water, solutes, or small molecules from the blood into the filtrate, or from the filtrate into the cells. Should a drug have an affinity for these transporters, it can accumulate within these cells and cause injury. As a result, there are many commonly-used pharmaceutical compounds which are nephrotoxic to some degree, which can lead to acute kidney injury in patients. The nephr..

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