The role of the chemokine “CCL2” in central cardiovascular control

Abstract

The cardiovascular system is under the constant control of a specialised neural network spanning a number of brain regions. This includes a distinct population of neurons found within the paraventricular nucleus (PVN) of the hypothalamus. Activation of these neurons increases sympathetic nerve activity to cardiovascular organs and raises blood pressure. The mechanisms driving increased activity in the network has not been fully elucidated. Recent evidence suggests that invasion of peripheral immune cells into key regions of the brain might play a role in this regard. The chemokine known as C-C- Ligand 2 (CCL2) is a key activator of peripheral immune cells in hypertension. Whether CCL2 facili..