Thesis / Dissertation

A structural understanding of interleukin- 11 signalling

Riley Dunstan Metcalfe, Michael Griffin (ed.)

Published : 2020

Abstract

Interleukin (IL)-11 is an IL-6 family cytokine with several described roles in normal human physiology, haematopoiesis and disease. IL-11 signals by forming a hexameric signalling complex with its two receptors, the IL-11 specific receptor IL- 11R alpha, and the receptor glycoprotein (gp) 130, which is also utilised by approximately 15 other cytokines. IL-11 signalling has been shown to have roles in several diseases, including gastrointestinal cancer and cardiovascular fibrosis. Despite the growing importance that has been assigned to IL-11 signalling in disease, little is known about the structure of IL-11, the structural mechanisms of IL-11 signalling, or the structural basis of existing ..

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