Improving Ovarian Cancer Care Along The Disease Trajectory: From Prevention to Disease Management

Abstract

The overarching objective of this thesis was to investigate key clinical care questions along the ovarian cancer disease trajectory and formulate strategies to improve care provision. This thesis focused on three time points on the trajectory: i) cancer prevention; ii) tolerability of experimental treatment at disease recurrence; and iii) development of malignant bowel obstruction. For women at high risk of developing ovarian cancer, such as those with a germline BRCA1 or BRCA2 mutation (gBRCA1/2mut), risk-reducing salpingo-oophorectomy (RRSO) is the most effective preventative method and recommended by peak bodies. RRSO involves complete resection of the ovaries and fallopian tubes up to ..