Thesis / Dissertation

Colorectal peritoneal metastases: Current status in treatment, evaluation of the immune landscape and development of a novel platform for personalised medicine

Vignesh Narasimhan, Alexander Heriot (ed.)

Published : 2020

Abstract

Peritoneal metastases from colorectal cancer confer the worst survival in patients with metastatic colorectal cancer. Historical survival from peritoneal metastases was dismal, with the condition generally viewed with nihilism. The adoption of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) can offer selected patients with colorectal peritoneal metastases (CRPM) a favorable survival. However, its uptake is variable due to skepticism about its efficacy. Additionally, most patients have inoperable disease, and are treated with systemic chemotherapy, fraught with high rates of treatment failures. With limited advances in management of peritoneal disease, there..

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