Thesis / Dissertation

Saving the hair cell: Investigating Apoptosis signal-regulating kinase 1 as a molecular target for preventing aminoglycoside induced hearing loss

Jacqueline Michelle Ogier, Paul Lockhart (ed.)

Published : 2020

Abstract

Aminoglycoside antibiotics are lifesaving medicines, crucial for the treatment of chronic or drug resistant infections. However, aminoglycosides can destroy the sensory hair cells of the ear. As a result, aminoglycoside treated individuals frequently experience a reduced quality of life, stemming from permanent high-frequency hearing loss and vestibular impairment. Currently, no alternate antibiotic substance has the same bactericidal profile or efficacy as aminoglycosides, and an adjuvant therapy capable of mitigating ototoxic outcomes does not exist. In order to develop an otoprotective therapy, the mechanisms of aminoglycoside-induced hair cell death must be elucidated. With respect to ..

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