Thesis / Dissertation

Morphological and functional studies in a sheep model of pulmonary fibrosis

Sasika Nimanthi Vithana Dewage, Kenneth Snibson (ed.)

Published : 2020

Abstract

Idiopathic pulmonary fibrosis is a lethal progressive respiratory disease with unknown aetiology that occurs predominantly in Western countries. The incidence and prevalence of this disease condition has been shown to be increasing over the years. IPF is localized to the lungs and diagnosed based on the radiologic and histopathological pattern of usual interstitial pneumonia (UIP). Two therapeutic drugs, pirfenidone and nintedanib, have been approved by the FDA in 2014 for treating IPF patients. While these drugs retard the progression of IPF, they do not cure it. Therefore, research is still required to better understand the underlying pathophysiology of IPF, and to develop therapies that h..

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University of Melbourne Researchers