Thesis / Dissertation

The Evaluation of Oxorhenium(V) and Oxotechnetium(V) Complexes for the Diagnosis of Alzheimer’s Disease

Benjamin Spyrou, Paul Donnelly (ed.)

Published : 2020

Abstract

Alzheimer’s disease (AD) is the most common neurodegenerative condition and is characterised by the presence of insoluble deposits within the brain that primarily consist of aggregated forms of the amyloid-beta (AB) peptide. The role that AB plays in the development and progression of AD remains uncertain. Accurate diagnostic information for suspected AD patients is imperative for the development of patient care plans, potential therapeutics and may aid in further understanding of AD pathology. The development of radiotracers that can bind to AB is of great interest as they can allow estimation of the plaque burden in patients that may have AD. Such compounds must bind specifically to AB pla..

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University of Melbourne Researchers