Developmental differences in the regulation and functional capacity of ABC efflux transporters at brain barrier interfaces

Abstract

The safety and potential risks of many medications used in treating pregnant women and newborn children are not well defined. This is, in part, due to limited knowledge of how readily drugs transfer into integral organs such as the brain early in development. The present Thesis investigated the expression, regulation and function of ATP-binding cassette (ABC) efflux transporters at brain, cerebrospinal fluid (CSF) and placental interfaces of the Sprague Dawley rat, highlighting age-dependent differences. The expression of eight main ABC efflux transporters (abcb1a/b, abcg2, abcc1-5) was described in the rat brain, choroid plexus and placenta, revealing distinct developmental profiles. Immuno..