The role of Complement and MHC in innate and adaptive immunity cooperation

Abstract

Major histocompatibility complex class II (MHC II) molecules are expressed by antigen presenting cells and essential for the development and activation of CD4+ T cells. Complement component 3 (C3) is the central component of the complement system and its activation is known to induce protective functions as part of the innate immune system. In this study, we have identified the unknown cooperation of these two central molecules of the adaptive and innate immune system, by describing their covalent association on the surface of conventional dendritic cells (cDCs). This in turn led to their ablation and enriched trogocytosis by marginal zone (MZ) B cells. We therefore describe two novel instan..