Thesis / Dissertation

Mathematical models of calcium signalling in the context of cardiac hypertrophy

Hilary Hunt, Edmund Crampin (ed.)

Published : 2020

Abstract

Throughout the average human lifespan, our hearts beat over 2 billion times. With each beat, calcium floods the cytoplasm of every heart cell, causing it to contract until calcium re-uptake allows the heart to relax, ready for the next beat. However, calcium is known to be critical in other cell functions, including growth. Calcium plays a central role in mediating hypertrophic signalling in ventricular cardiomyocytes on top of its contractile function. How intracellular calcium can encode several different, specific signals at once is not well understood. In heart cells, calcium release from ryanodine receptors (RyRs) triggers contraction. Under hypertrophic stimulation, calcium relea..

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