Thesis / Dissertation

Explaining the mechanisms underlying the effect of adiposity on the risk of colorectal, postmenopausal breast, and endometrial cancer using data from four prospective cohort studies

Seyedeh Ghazaleh Dashti, Dallas English (ed.)

Published : 2020

Abstract

Background Excess adiposity in adulthood is an established risk factor for several types of cancer, including colorectal, estrogen receptor (ER)-positive postmenopausal breast, and endometrial cancers. Dysregulated adipocytokine production and chronic low-grade inflammation, insulin resistance and hyperinsulinemia, and alteration in levels of sex-steroid hormones are three of the mechanisms hypothesised to explain the effect of adiposity on cancer risk. Current evidence suggests that these mechanisms are interconnected, and their relative importance is likely different for different cancers. Mediation analysis is a statistical method for quantifying how much of the effect of an exposure (..

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