Thesis / Dissertation

Peripheral quantitative computed tomography (pQCT)-based finite element modelling and its application in different populations

Hongyuan Jiang, John Wark (ed.)

Published : 2020

Abstract

Background: Dual energy X-ray absorptiometry (DXA), as the most established tool for the assessment of bone fragility, has limitations in identifying individuals with increased fracture risk. Peripheral quantitative computed tomography (pQCT) can provide additional information about bone fragility compared with DXA alone. The three-dimensional data acquired by peripheral quantitative computed tomography are a potential source to generate finite element analysis (FEA) models to further estimate bone mechanical properties. Aims: This doctoral project aimed to establish a FEA model based on pQCT data (pQCT-FEA) and to investigate its role in the assessment of bone fragility in three population..

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