Thesis / Dissertation

Characterisation of bromodomain proteins in the malaria parasite Plasmodium falciparum

Thi Hong Hanh Nguyen, Michael Duffy (ed.)

Published : 2020

Abstract

Plasmodium falciparum is a protozoan parasite that is responsible for the most severe and fatal form of human malaria. In addition to the canonical histones, the parasite possesses divergent and Apicomplexa-specific histone variants. The N-terminal tails of histones in P. falciparum are extensively acetylated and carry unique acetylation marks. P. falciparum relies on this network of histone post-translational modifications and interactive, chromatin-associated proteins to modulate its gene expression. Integral to this process are bromodomain (BRD) histone reader proteins which interact with acetylated lysine. The rapid emergence and development of human BRD inhibitors for the treatment of m..

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